Motif ID: RXR{A,B,G}.p2

Z-value: 2.590


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRBchr6_-_33168163-0.701.9e-05Click!
RXRAchr9_+_1372183240.604.6e-04Click!
RXRGchr1_-_165414499-0.412.3e-02Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_21242592 7.313 NM_173505
 ANKRD29
ankyrin repeat domain 29
chr16_-_87903028 7.081 NM_003486
 SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr9_+_131185129 6.564 CERCAM
cerebral endothelial cell adhesion molecule
chr19_-_51472003 6.197 NM_001012964
NM_001012965
 KLK6

kallikrein-related peptidase 6

chr16_-_85784628 6.155 NM_206967
 C16orf74
chromosome 16 open reading frame 74
chr12_-_57634474 6.064 NM_020142
 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr20_-_56284945 5.775 NM_020182
 PMEPA1
prostate transmembrane protein, androgen induced 1
chr1_-_154946859 5.003 NM_001130041
NM_001202859
NM_003029
 SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr10_+_88718287 4.991 NM_003087
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr19_-_14228560 4.924 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr5_-_172755195 4.670 STC2
stanniocalcin 2
chr17_-_76921205 4.495 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_43737937 4.476 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
 VEGFA

















vascular endothelial growth factor A

















chr7_+_40174594 4.466 C7orf10
chromosome 7 open reading frame 10
chr1_-_154946830 4.423 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr12_-_54812936 4.392 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_-_41858948 4.364 TGFB1
transforming growth factor, beta 1
chr12_-_25055228 4.342 NM_001178094
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr5_+_149865310 4.332 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr15_-_74494851 4.309 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 88 entries
enrichment   p-value GO term description
2.97 1.37e-03 GO:0008064 regulation of actin polymerization or depolymerization
2.88 2.64e-03 GO:0030832 regulation of actin filament length
2.83 2.98e-02 GO:0030833 regulation of actin filament polymerization
2.78 4.05e-02 GO:0050680 negative regulation of epithelial cell proliferation
2.67 7.55e-03 GO:0032271 regulation of protein polymerization
2.30 3.83e-02 GO:0032956 regulation of actin cytoskeleton organization
2.18 4.32e-02 GO:0043254 regulation of protein complex assembly
2.17 1.11e-02 GO:0050678 regulation of epithelial cell proliferation
2.14 5.00e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.08 1.43e-04 GO:0051129 negative regulation of cellular component organization
1.97 1.13e-02 GO:0044087 regulation of cellular component biogenesis
1.96 1.50e-05 GO:0007411 axon guidance
1.91 6.95e-05 GO:0032535 regulation of cellular component size
1.83 9.65e-04 GO:0033043 regulation of organelle organization
1.80 1.31e-02 GO:0071900 regulation of protein serine/threonine kinase activity
1.78 8.80e-04 GO:0090066 regulation of anatomical structure size
1.77 2.45e-02 GO:0051270 regulation of cellular component movement
1.70 1.49e-03 GO:0048812 neuron projection morphogenesis
1.70 5.85e-03 GO:0010627 regulation of intracellular protein kinase cascade
1.70 1.45e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.60 4.80e-03 GO:0005604 basement membrane
2.10 2.62e-02 GO:0044420 extracellular matrix part
2.05 1.43e-02 GO:0005938 cell cortex
1.86 2.42e-02 GO:0031252 cell leading edge
1.69 1.31e-02 GO:0015629 actin cytoskeleton
1.32 3.35e-02 GO:0000267 cell fraction
1.28 4.78e-04 GO:0005829 cytosol
1.13 6.34e-06 GO:0005737 cytoplasm
1.13 2.30e-03 GO:0044444 cytoplasmic part
1.07 2.91e-03 GO:0044424 intracellular part
1.07 3.66e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
2.57 2.70e-03 GO:0005201 extracellular matrix structural constituent
1.53 2.68e-03 GO:0005198 structural molecule activity
1.34 4.97e-02 GO:0030528 transcription regulator activity
1.18 2.46e-10 GO:0005515 protein binding
1.06 1.42e-02 GO:0005488 binding